11/25/2023 0 Comments Apixaban antidoteProthrombin time (PT) / international normalized ration (INR) is a measure of the extrinsic and common pathway it is useful to determine the anticoagulation status of patients receiving VKAs. Prothrombin Time (PT) and International Normalized Ratio (INR) See Figure 1 for an overview of the coagulation cascade and site of action of the anticoagulants. Note that each direct factor Xa inhibitor has the letters “Xa” in its spelling. The DOACs act directly upon Factors IIa (DTIs) or Xa (“Xabans”) without using antithrombin as a mediator. Examples of DOACs include the following: direct thrombin inhibitors (DTIs) dabigatran (Pradaxa) and direct factor Xa inhibitors (“Xabans”) rivaroxaban (Xarelto), apixaban (Eliquis) and edoxaban (Lixiana, Savaysa). Target-specific oral anticoagulants (TSOACs) or direct oral anticoagulants (DOACs) were developed to provide more stable pharmacokinetic and pharmacodynamic options for oral anticoagulation. VKAs reduce the synthesis of factors II, VII, IX and X thereby reducing ability to generate active thrombin, rather than inhibition of activated enzymes. Once an injectable indirect factor Xa and IIa inhibitor has been selected, an oral vitamin K antagonist (VKA), traditionally warfarin (Coumadin), is started on the same day. Finally, Fondaparinux (Arixtra) is an exclusive indirect factor Xa inhibitor. Enoxaparin (Lovenox), a low-molecular-weight-heparin (LMWH), inhibits factors Xa and to a lesser extent IIa. UFH also inhibits factors XIIa, XIa and IXa. Examples of injectable indirect factor Xa and IIa inhibitors include unfractionated heparin (UFH), which inhibits factors Xa and to a lesser extent IIa. Physicians have numerous anticoagulation treatment options in their arsenal including the traditional injectable indirect factor Xa and IIa (thrombin) inhibitors, which are mediated through an antithrombin dependent mechanism.
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11/25/2023 0 Comments Unlacquered brass drawer pullsJust peek into any famous designer’s portfolio and you’ll see brass. It’s a classic design element that adds warmth to any space and gives it a high-end feel. Don’t let this stand in your way of using real, raw brass in your home. “Coastal Grandma” made its way into the fashion world, but the yellow shiny glam look of “80’s Grandma” is the stuff design nightmares are made of. It all starts out with the same bright beautiful gold color making it easy for you to mix and match pieces in your designs. The only type of brass that will be the same no matter where you find it is unlacquered brass. Learn the easiest way to hang drapes if interested in learning more about that. I had an old brass drape rod but the manufacturer didn’t sell matching rings…grrr! It took some trial and error to find what I was looking for. I learned this lesson when trying to hang my drapes. Do they look nice, sure! The problem is they are usually specific to manufacturers making it hard to find matches. We don’t know their long-term durability and they certainly don’t have the longevity that brass does. Many retailers offer finishes like honey or champagne bronze as a “toned-down” alternative for those unsure of brass. If brass is lacquered, it will be protected and no longer susceptible to the effects of moisture or oxygen. It’s what gives unlacquered brass hardware that beautiful patina you see and puts it into the living finish category. This happens when brass comes into contact with oxygen, water, and even the oils in your skin. Without anything to protect it, the once shiny finish will become dull and darker over time. Unlacquered brass is considered raw brass because it doesn’t have any protective coating (lacquer). Who would do such a thing?ĭoor Latches | Drawer Pulls | Round knobs That wasn’t actually brass but part of an unfortunate design trend where metal was painted to mimic brass without the price tag. Even though unlacquered brass starts off with a bright finish, there is no mistaking it for that shiny gold lamp at Grandma’s house.
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11/24/2023 0 Comments Db shrugs ss pulloversOnce you’ve reached the top of the lift, hold the weight for as long as you can. This is when you’ve reached muscle failure on the “positive” part of the lift-where your muscles are contracting and you’re going to the “top” of the movement. Lastly, Mentzer used a lot of negative reps. Once again, you want to go to complete failure, so repeat this 3 or 4 times when you think you’ve finished a set. Then, push out another rep, resting afterward if necessary. Once you’ve reached a point where you can’t bring the weight back up with a full contraction of your muscles, pause at the bottom of the lift until you’ve caught your breath. This goes on until you can’t even hold the weight for any longer. This is when a spotter helps you out-when you can’t lift the weight anymore on your own, the spotter is supposed to assist you until you can get 3 to 4 more reps out of your muscles. One of the ways he trained till failure was by using forced reps. This was exemplified in his massive biceps, which he would work on till failure for one hour each week, keeping constant tension on them. This concept of absolute failure played a lot into his training, as he advocated for completely destroying a muscle group before letting it recover for a few days. How heavy? You’re supposed to reach absolute failure in that number of reps. The 20-rep sets turned to sets with 6 to 9 reps instead, and the weights were made much heavier. Taking Arthur Jones’ form of high-intensity training, Mentzer ramped things up a notch. This training system was the basis of Dorian Yates’ training, making him a six-time Mr. This led to the Heavy Duty training, which took Mentzer’s musings on fitness and health, and how to get muscle growth as quickly as possible. Once writing that “Man is an indivisible entity, an integrated unit of mind and body,” Mentzer was to many as much philosopher as he was bodybuilder. Throughout the years, he studied physiology and kept up to date with the most recent publications. America with his revamped high-intensity training program. In 1971, he was introduced to Arthur Jones, the creator of high-intensity training for bodybuilding.įive years later in 1976, Mentzer would go on to win Mr. Mentzer began lifting when he was only 12 years old, and by the age of 15, he could bench over 350 pounds. It’s definitely going to gas out your muscles and get you results, but it’s not for those looking to coast their way to a great physique. We’ve taken a closer look at the mind behind this training philosophy, and the things that led up to it. Even during the time, Mentzer’s thinking went against the grain, both in terms of his lifting and his diet. As the name would suggest, this routine isn’t for the light of heart.Ĭreated by Mike Mentzer (1951 – 2001)-as much philosopher as he was bodybuilder-the Heavy Duty method is one that incorporates high-intensity training along with lower rep ranges and heavier weights. Hope everyone else has a great workout today like I did.One of the most intense training regimes out there for bodybuilding is known as the “Heavy Duty” method. Today's workout was great, had a fantastic pump going on and increase the weight in all movements which is excellent. The Gun show will be going on for the next couple of months and I would like to see some of you here again. Well I hope you all enjoyed the GUN SHOW today and found many that you like. Have a great day everyone.Ģx8x95 (up from last week which was 3sets of 6)ĥ sec pause at top of curl from rep 7-10, this hurts like a biotch. Really looking forward to this show coming up and whooping some ass. Which means I worked my ass off which is a good thing. I was on the verge of throwing up from todays workout. STANDING CALF RAISES (left calf only ss'ed w/ Donkey)Īll I can say about todays leg trashing is damnnnnnn. I am offically 26 weeks out from the Texas Shredder.īoth squats and front squats were done in 25min. Was sweating like a cold drink on a hot humid day. Today's work out was brutal is all I am going to say.ġX10These were supersetted with each other w/ only 30-45sec rest between setsġX7X225These were supersetted with each other w/ only 30-45sec rest between setsġx20x50 5sec pause at top on rep 5,10,15,20ġx20x80 5sec pause at top on rep 5,10,15,20 I also have a long term goal and that is to place in the top 5 at the Texas Shredder which is 27 weeks out. That is in the past and I now have a new short term goal to reach for the next 12 weeks. I did mananged to bench press 350lbs for 2rep. I missed my goal weight by 5lbs and the other goals I had I missed them also. 11/24/2023 0 Comments Undyne the undying fight simulator
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